WebINCB106385 is a dual inhibitor of A2A and A2B receptors, which may prevent immune suppression in the tumor microenvironment and promote anti-tumor immune response … WebJul 1, 2024 · INCB106385 is a potent, selective and orally bioavailable dual antagonist of A2A and A2B receptors. In vitro, INCB106385 potently binds to both A2A and A2B …
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WebDec 8, 2024 · INCB106385 was generally well tolerated in pts with advanced solid tumors, with asthenia and gastrointestinal events being the most common TEAEs. Doses ≥80 mg BID were sufficient for target inhibition in most pts. Further dose escalation is ongoing in parallel with dose expansion. Clinical trial identification NCT04580485. Editorial … WebJul 11, 2024 · INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors STATUS Recruiting End date Apr 10, 2024 participants needed 230 sponsor Incyte Corporation Print Send Updated on 11 July 2024 See if I qualify cancer measurable disease bladder tumor cancer of the ovary Summary WebFeb 3, 2024 · INCB-106385 Etrumadenant Ciforadenant Selatogrel TT-4 TT-10 DZD-2269 Ciforadenant Key Topics Covered: Introduction Executive Summary Purinergic Receptor (Purinoceptor) Antagonists: Overview... bitesize non fiction