Eif4a3 rbp
WebJun 28, 2024 · In addition, EIF4A3, an RNA-binding protein (RBP), could inhibit the formation of circRNA_100290 by binding to the flanking sites of circRNA_100290. Low EIF4A3 expression in GC was related to a poor prognosis. WebNov 15, 2024 · RNA Stability Measurement Transfected cells (sh-NC, sh-EIF4A3) were seeded in culture dishes with 2 μg/mL actinomycin D (ActD, NobleRyder, China) to block de novo RNA synthesis. Total RNA was …
Eif4a3 rbp
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WebDec 3, 2024 · (A) Potential binding site between EIF4A3 and hsa_circ_0068631 according to CircInteractome. (B) Pull-down silver staining was used to demonstrate the potential RBPs binding to hsa_circ_0068631. (C) Interaction between EIF4A3 and hsa_circ_0068631 was demonstrated by an RNA pull-down assay. WebFeb 18, 2024 · accounting involves using auditing quantitative methods and related investigative skills to reconstruct financial records and determine if fraud or
WebOct 29, 2024 · In conclusion, CircETFA can increase the expression of CCL5 to promote the progression of HCC by sponging hsa-mir-612 and recruiting EIF4A3, and is promising as a novel biomarker and therapeutic... WebJun 30, 2024 · For instance, the RBP UNR/CSDE1 promotes cell invasion and metastasis in melanoma . RBP NOVA1 functions as a malignancy promoter in melanoma via modulating FOXO3a expression [40, 41]. Previous research has identified that EIF4A3 influences the development of certain cancers via acting as a RBP . It was revealed in our study that …
WebJul 15, 2024 · Eukaryotic initiation factor 4A3 (EIF4A3, DDX48) is a member of the DEAD box family, which is one of the largest helicase families characterized by an Asp-Glu-Ala-Asp (DEAD) motif . ... “RBP mediated circularization”, RBP interacts with the intron binding sites to make the splice sites closer to induce circularization. ...
WebJul 23, 2024 · It was predicted that eIF4A3 was the RBP of hsa_circ_0002594. Meanwhile, some researchers performed quantitative proteomics to analyze eIF4A3 protein expression and its binding mRNA expression based on stable isotope labeling (SILAC) of amino acids in cell culture, and the results showed that eIF4A3 combined with PTEN mRNA . Actually, …
WebDec 3, 2024 · EIF4A3 is a core component of the exon junction complex (EJC), playing significant roles in mRNA splicing, location, transport, translation, and degradation. 30, … range function parameters pythonWebJun 9, 2024 · Our findings suggested that EIF4A3-induced circFIP1L1 repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity by miR … owen hanWebMar 10, 2024 · Interestingly, Dudekula et al. used an innovative web tool (CircInteractome, for circRNA interactome) to map the RBP-binding sites in the flanking sequences upstream and downstream of mature circRNAs. By specifically using circ_0000020, they provided evidence of multiple binding sites for HuR, FMRP, and EIF4A3 . owen hand towelPrompted by the large number of TFEB targets identified from our RNA-seq analysis, we further investigated a potential role for TFEB in the eIF4A3-mediated transcriptional response. Interestingly, we found that endogenous TFEB displayed a clear downward shift by western blotting in response to eIF4A3 … See more Intrigued by the steadily increasing evidence for several new and previously unrecognized functions of RBPs, we recently performed a … See more eIF4A3 has been attributed several biological roles related to RNA homeostasis, including NMD, splicing, mRNA localization, … See more To investigate this phenotype in closer detail, we explored both early and late stages of the autophagy pathway. Immunofluorescent (IF) stains for the phagophore … See more To further verify the role of eIF4A3 in mediating the observed phenotypes, we created MCF-7 GFP-LC3B cells with doxycycline-inducible expression of eIF4A3, which led to a reduction in LC3B lipidation levels as … See more owen hansen trackwrestlingWebJun 9, 2024 · As an important RNA-binding protein, EIF4A3 was revealed to be involved in RNA exon splicing by forming exon junction complexes [ 30 ]. Moreover, EIF4A3 has been found to play a key role in regulating the progression of various tumors, such as breast cancer, glioblastoma, ovarian cancer [ 31, 32, 33 ]. range function python syntaxWebMar 1, 2024 · RNA-binding protein (RNA-RBP) 1. Introduction Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disease caused by excessive hypertrophy of the myocardium and characterized by thickening of the left ventricular wall [ 1 ]. owen harding missingWebPurpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in ... owen hanson